The NFL record for most points scored in a single game is held by the Washington Redskins, who scored 72 points in a game against the Giants in 1966. However, it is highly unlikely that any NFL team has ever scored 100 points in a single game due to the rules and regulations of the league. The highest combined score in a single NFL game is 113 points, set when the Los Angeles Rams defeated the Baltimore Colts in 1950. Additionally, the highest point total by a team in a single quarter is 45 points, set by the Kansas City Chiefs in 2003. As a result, it is safe to say that an NFL team has never scored 100 points in a single game.